danuser lab

harvard medical school :: department of cell biology :: laboratory for computational cell biology

We study how mechanical and chemical signals integrate in space and time to control cytoskeleton dynamics and membrane trafficking. We develop a minimally-perturbing experimental approach that exploits the intrinsic heterogeneity of cell dynamic states to probe the hierarchy and kinetics of mechanochemical signaling cascades.

read our latest paper

Analysis of microtubule dynamic instability using a plus-end growth marker

Matov, A. et al., Nature Methods 7, 761-768 (1 September 2010)

read our collaborators' latest paper

Phosphatidic Acid Plays a Regulatory Role in Clathrin-mediated Endocytosis

Antonescu, C. et al., Mol. Biol. Cell 12, 2944-2952 (15 August 2010)

news

August 1, 2010:: Marco Vilela joins LCCB as a postdoctoral fellow. His position is funded by the grant T-R01 GM90317. He will work on new mathematical methods to reconstruct signal transduction pathways from image fluctuations.
June 1, 2010:: Kwonmoo Lee and Uli Schmidt join LCCB as postdoctoral fellows. Kwonmoo's position is funded by the grant R01 GM071868. He will study the coordination of multiple, specialized actin nucleation proteins in generating cell migration forces. Uli's position is funded by a fellowship donation by Applied Precsion, Inc., Issaquah, WA. He will develop new single molecule imaging approaches to elucidate the spatial and temporal coordination of cell surface receptors.
April 5, 2010:: Anindya Chanda joins LCCB as a postdoctoral fellow. His position is funded by the grant U01 GM067230. He will work on single-molecule imaging studies of CD36 receptor dynamics.
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