“We study how mechanical and chemical signals integrate in space and time to control cytoskeleton dynamics and membrane trafficking. We develop a minimally-perturbing experimental approach that exploits the intrinsic heterogeneity of cell dynamic states to probe the hierarchy and kinetics of mechanochemical signaling cascades.” read our latest paper
Delivery of membrane impermeable cargo into CHO cells by peptide nanoparticles targeted by a protein corona
Dittrich, C. et al., Biomaterials 33(9), 2746-53 (March 2012) read our collaborators' latest paper
High Refractive Index Silicone Gels for Simultaneous Total Internal Reflection Fluorescence and Traction Force Microscopy of Adherent Cells
Gutierrez, E. et al., PLoS One 6(9) (September 2011) |
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news
| February 6, 2012 | :: | Nancy Costigliola joins LCCB as a postdoctoral fellow. She will be working on cell biological and live cell imaging based analyses of the roles of vimentin intermediate filaments in cell migration. |
| January 1, 2012 | :: | Youbean Oak joins LCCB as a MCB graduate student. She will be working on cell biological and live cell imaging based analyses of the roles of fascin in cancer cell migration. Kwonmoo Lee receives a fellowship for 24 months from the NIH to work on the project "Spatiotemporal Coordination of Formin and Arp2/3 in Epithelial Cell Migration." Congratulations! |
| December 5, 2011 | :: | Liya Ding joins LCCB as a postdoctoral fellow. She will be working on the development of novel algorithms for the analysis of dynamic interactions between cytoskeleton systems. |
| November 15, 2011 | :: | Danuser receives a multi-PI R01 grant from the NIH, jointly with Ralph Weissleder at MGH, Peter Sorger and Tim Mitchison in HMS Systems Biology, to analyze by quantitative intravital imaging pharmacological mechanisms in anti-cancer chemotherapy. The project is funded for five years. Our lab is responsible for the development of image analysis software to track individual cell response to drug application and for the integration of this data in pharmacokinetic/dynamic models. We have an opening for a postdoctoral position in this project. |
| November 1, 2011 | :: | Danuser receives a NIH Program Project grant together with the Hanein, Horwitz, Ginsberg, Schwartz, and Volkmann labs to study the structural basis of mechanotransduction in cell matrix adhesions. The project is funded for five years. Our lab in particular will focus developing high-resolution imaging methods and quantitative analysis of the functional linkages between force transduction, protein recruitment, and Rho GTPase signal activation in different adhesion types. We still have opportunities for postdocs interested in working on experimental or analytical aspects. Please contact Gaudenz Danuser if you are interested. |
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